Article
Detection of MAGE-A3 in breast cancer patients' sentinel lymph nodes.
British journal of cancer - 2 Nov 2001
Wascher R A, Bostick P J, Huynh K T, Turner R, Qi K, Giuliano A E, Hoon D S
Abstract excerpt
The detection of occult metastatic breast cancer cells by RT-PCR is limited by the poor specificity of most tumour mRNA markers. MAGE-A3 is a highly specific tumour mRNA marker that is not expressed in non-cancer cells. This study assesses MAGE-A3 mRNA as a molecular marker for the detection of tumour cells in the sentinel lymph nodes (SLN) of breast cancer patients. Serial frozen sections of SLN (n = 121) were...
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