Article
A large Icelandic family with early osteoarthritis of the hip associated with a susceptibility locus on chromosome 16p.
Arthritis and rheumatism - 1 Nov 2001
Ingvarsson T, Stefánsson S E, Gulcher J R, Jónsson H H, Jónsson H, Frigge M L, Pálsdóttir E, Olafsdóttir G, Jónsdóttir T, Walters G B, Lohmander L S, Stefánsson K
Abstract excerpt
OBJECTIVE: To describe a large kinship with inherited hip osteoarthritis (OA) and its associated susceptibility locus. METHODS: Four generations of a kinship with familial hip OA were identified and characterized by family history and by clinical, radiographic, and histopathologic examination. In the genome-wide search for a susceptibility locus, OA cases were defined as those who had undergone total hip...
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