Article
International prognostic scoring system and TP53 mutations are independent prognostic indicators for patients with myelodysplastic syndrome.
British journal of haematology - 1 Nov 2001
Kita-Sasai Y, Horiike S, Misawa S, Kaneko H, Kobayashi M, Nakao M, Nakagawa H, Fujii H, Taniwaki M
Abstract excerpt
We applied the International Prognostic Scoring System (IPSS) to our series of 118 patients with myelodysplastic syndrome (MDS) to determine its validity, and also used univariate and multivariate analyses to evaluate the prognostic significance of TP53 configurations. Sixteen patients with the mutation had a strikingly worse prognosis and the multivariate analysis demonstrated that this alteration was the most...
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