Article
Functional variation of MC1R alleles from red-haired individuals.
Human molecular genetics - 1 Oct 2001
Healy E, Jordan S A, Budd P S, Suffolk R, Rees J L, Jackson I J
Abstract excerpt
Red hair in humans is associated with variant alleles of the alphaMSH receptor gene, MC1R. Loss of MC1R function in other mammals results in red or yellow hair pigmentation. We show that a mouse bacterial artificial chromosome (BAC) which contains Mc1r will efficiently rescue loss of Mc1r in transgenic mice, and that overexpression of the receptor suppresses the effect of the endogenous antagonist, agouti...
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