Article
Origin of bovine IgM structural variants.
Molecular immunology - 1 Sept 2001
Saini S S, Kaushik A
Abstract excerpt
The structure of IgM determined from two cDNAs isolated from a Holstein (BLV7G1) and an Angus x Hereford cross-bred (B5D8) cow reveals high sequence similarity both at nucleotide (98.7%) and amino acid (97.9%) level and is closest to sheep (89.4%). Three bovine IgM allotypes, designated as IgMa, IgMb and IgMc, are classified based on nucleotide substitutions in all the Cmu exons resulting in amino acid...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cattle
- DNA, Complementary
- Genetic Variation
- Immunoglobulin Allotypes
- Immunoglobulin Constant Regions
- Immunoglobulin M
- Immunoglobulin mu-Chains
- Mice
- Molecular Sequence Data
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- RNA Splice Sites
