Article
Ext-mutation analysis in Italian sporadic and hereditary osteochondromas.
International journal of cancer - 20 Nov 2001
Gigante M, Matera M G, Seripa D, Izzo A M, Venanzi R, Giannotti A, Digilio M C, Gravina C, Lazzari M, Monteleone G, Monteleone M, Dallapiccola B, Fazio V M
Abstract excerpt
Osteochondromas represent the largest group of benign tumors of bone. Multiple osteochondromatosis or hereditary multiple exostoses (EXT) is an autosomal dominant inherited disorder characterized by the presence of multiple benign cartilage-capped exostoses. EXT is genetically heterogeneous with at least 3 chromosomal loci: EXT1 (8q24.1), EXT2 (11p11-p13), and EXT3 (19p). In <5% of EXT patients, the inactivation...
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