Antiretroviral Resistance Mutations among Pregnant Human Immunodeficiency Virus Type 1–Infected Women and Their Newborns in the United States: Vertical Transmission and Clades

Abstract excerpt

To assess the impact of antiretroviral resistance on perinatal transmission prevention efforts, human immunodeficiency virus type 1 (HIV-1) genotypic resistance testing was done for 220 HIV-1-infected, zidovudine (AZT)-exposed pregnant women and 24 of their infected infants. The women were prospectively enrolled in 4 US cities in 1991-1997. Phylogenetic and sequencing analyses revealed 5 women with non-clade B...

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