Article
Conversion of a peroxiredoxin into a disulfide reductase by a triplet repeat expansion.
Science (New York, N.Y.) - 5 Oct 2001
Ritz D, Lim J, Reynolds C M, Poole L B, Beckwith J
Abstract excerpt
Pathways for the reduction of protein disulfide bonds are found in all organisms and are required for the reductive recycling of certain enzymes including the essential protein ribonucleotide reductase. An Escherichia coli strain that lacks both thioredoxin reductase and glutathione reductase grows extremely poorly. Here, we show that a mutation occurring at high frequencies in the gene ahpC, encoding a...
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