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Development of Dengue virus type 2 replicons capable of prolonged expression in host cells

24 Aug 2001

Abstract excerpt

BACKGROUND: As part of a program to develop a Dengue virus vaccine which avoids the deleterious effects of antibody dependent enhancement (ADE) of infection mediated by antibodies to Dengue virus structural proteins, we have begun to investigate the possibility of designing Dengue vaccines based on non-structural proteins. RESULTS: Dengue constructs which lack major structural proteins replicate intracellularly...

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PMID: 11580862
DOI: 10.1186/1471-2180-1-18

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