Article
Anti-fibrillin-1 autoantibodies in systemic sclerosis are GM and KM allotype-restricted.
Experimental and clinical immunogenetics - 1 Jan 2001
Pandey J P, Page G P, Silver R M, LeRoy E C, Bona C A
Abstract excerpt
GM and KM allotypes--genetic markers of immunoglobulin (Ig) gamma and kappa chains, respectively--have been shown to play an important role in genetic predisposition to some autoimmune diseases. To determine their role in susceptibility to systemic sclerosis (SSc; scleroderma) and in the generation of anti-fibrillin-1 antibodies, 148 SSc patients and 191 controls were typed for several GM and KM allotypes by a...
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