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Article

Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells

21 Aug 2001

Abstract excerpt

Pro-protein convertases such as furin are expressed in many human tumor lines and primary tumors. Furin processes stromelysin-3, membrane type 1 matrix metalloproteinase (MMPs) involved in tumor cell invasiveness, as well as growth factors such as transforming growth factor beta1. Evaluation of furin expression in head and neck squamous cell carcinoma (HNSCC) cells exhibiting different invasive ability showed...

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PMID: 11517338
DOI: 10.1073/pnas.191199198

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