Article
Idiopathic gonadotrophin deficiency: genetic questions addressed through phenotypic characterization.
Clinical endocrinology - 1 Aug 2001
Quinton R, Duke V M, Robertson A, Kirk J M, Matfin G, de Zoysa P A, Azcona C, MacColl G S, Jacobs H S, Conway G S, Besser M, Stanhope R G, Bouloux P M
Abstract excerpt
OBJECTIVE: The association of idiopathic hypogonadotrophic hypogonadism (IHH) with congenital olfactory deficit defines Kallmann's syndrome (KS). Although a small proportion of IHH patients have been found to harbour defined genetic lesions, the genetic basis of most IHH cases remains to be elucidated. Genes currently recognized to be involved comprise KAL (associated with X-linked-KS), the GnRH receptor...
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