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Article

Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia

28 Aug 2001

Abstract excerpt

Therapy-related acute myeloid leukemias (t-AML) with translocations of the MLL gene are associated with the use of topoisomerase II inhibitors. We established the emergence of the malignant clone in a child who developed t-AML with a t(11;19) (q23;p13.3) during treatment for acute lymphoblastic leukemia (ALL). The MLL-ENL and the reciprocal ENL-MLL genomic fusions and their chimeric transcripts were characterized...

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PMID: 11526240
DOI: 10.1073/pnas.181199898

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