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Article

Disease model: hyperinsulinemia and insulin resistance. Part B--polygenic and other animal models.

Trends in molecular medicine - 1 Aug 2001

Sone H, Takahashi A, Iida K, Yamada N

Abstract excerpt

Deficiency of leptin or its receptor produces hyperinsulinemia with marked obesity. Paradoxically, severe insulin resistance also accompanies lipodystrophy. Animal models of these contrasting conditions have enabled us to observe the profound and complicated aspects of the underlying pathologies. In addition, conventional polygenic rodents with known genetic backgrounds, such as the spontaneously hypertensive rat...

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Identifiers

PMID: 11516999
DOI: 10.1016/s1471-4914(01)02072-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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