Nature of the Spermatogenic Arrest in Dazl −/− Mice

doi:10.1095/biolreprod65.3.771

Article

Nature of the Spermatogenic Arrest in Dazl −/− Mice

1 Sept 2001

Abstract excerpt

Dazl encodes an RNA-binding protein essential for spermatogenesis. Mice that are deficient for Dazl are infertile, lacking any formation of spermatozoa, and the only germ cells present are spermatogonia and a few spermatocytes. To gain more insight regarding the timing of the spermatogenic arrest in Dazl -/- mice, we studied the spermatogonial cell types present in testis sections and in seminiferous tubular...

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