Article
Correlation between the expression of cyclin A protein and p53 activity in oral squamous cell carcinomas.
Cytobios - 1 Jan 2001
Chen Q, Zhou H, Guo W, Samaranayake L P, Zhou M, Li B
Abstract excerpt
Cyclins and wild-type p53 protein are prime cell cycle regulators and may be involved in tumorigenesis. Cyclin A is a late S cyclin and its abnormalities have been reported in several cancers, including oral squamous cell carcinomas. To explore whether aberrant G1/S in p53 mutant tumours leads to increased cyclin A protein in oral squamous cell carcinomas (OSCC), a total of 39 samples were evaluated for the...
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