Article
Immunological phenotyping of fibroblast cultures from patients with a mitochondrial respiratory chain deficit.
Laboratory investigation; a journal of technical methods and pathology - 1 Aug 2001
Williams S L, Scholte H R, Gray R G, Leonard J V, Schapira A H, Taanman J W
Abstract excerpt
Conventional approaches to the diagnosis of mitochondrial respiratory chain diseases, using enzyme assays and histochemistry, are laborious and give limited information concerning the genetic basis of a deficiency. We have evaluated the diagnostic value of 12 monoclonal antibodies to subunits of the four respiratory chain enzyme complexes and F(1)F(0)-ATP synthase. Antibodies were used in immunological studies...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.