Article
New morphological approaches to the study of mitochondrial encephalomyopathies.
Brain pathology (Zurich, Switzerland) - 1 Apr 1992
Bonilla E, Sciacco M, Tanji K, Sparaco M, Petruzzella V, Moraes C T
Abstract excerpt
Molecular genetics, biochemistry, immunology and morphology, are being applied in a coordinated fashion to unveil the molecular basis of the mitochondrial encephalomyopathies. Mutations of mitochondrial DNA (mtDNA) have been found in well characterized clinical groups of these disorders. New and old morphologic methods have been applied to investigate muscle biopsies from patients with mtDNA mutations. Important...
Topics
- DNA, Mitochondrial
- Electron Transport Complex IV
- Fluorescent Dyes
- Humans
- In Situ Hybridization
- Mitochondrial Encephalomyopathies
- Mutation
- Succinate Dehydrogenase