Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural Alterations of Gene Complexes by Cystic Fibrosis Sputum

1 Aug 2001

Abstract excerpt

Gene complexes with optimal physicochemical characteristics for cystic fibrosis (CF) gene therapy in vitro may become inactive in vivo as a result of destruction upon interaction with CF mucus. Therefore, we examined in this study to what extent main sputum components (linear DNA, mucin, phosphatidylcholine, phosphatidylglycerol, and albumin) may disintegrate lipoplexes. We found that mixing linear DNA with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystic Fibrosis Research Advances
Share to Neonatal Respiratory Health Research
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11500355
DOI: 10.1164/ajrccm.164.3.2011041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural Alterations of Gene Complexes by Cystic Fibrosis SputumPMID 11500355Read ↗

Optimizations of In Vitro Mucus and Cell Culture Models to Better Predict In Vivo Gene Transfer in Pathological Lung Respiratory Airways: Cystic Fibrosis as an ExampleSemantic proximity Read ↗

Novel molecular approaches to cystic fibrosis gene therapySemantic proximity Read ↗

Compacted DNA Nanoparticles Administered to the Nasal Mucosa of Cystic Fibrosis Subjects Are Safe and Demonstrate Partial to Complete Cystic Fibrosis Transmembrane Regulator ReconstitutionSemantic proximity Read ↗

Inhaled gene therapy of preclinical muco-obstructive lung diseases by nanoparticles capable of breaching the airway mucus barrierSemantic proximity Read ↗

Delivery of genes into the CF airwaySemantic proximity Read ↗

A Receptor-targeted Nanocomplex Vector System Optimized for Respiratory Gene TransferSemantic proximity Read ↗

Physical and Biological Barriers to Viral Vector–mediated Delivery of Genes to the Airway EpitheliumSemantic proximity Read ↗

Assisting PNA Transport Through Cystic Fibrosis Human Airway Epithelia With Biodegradable Hybrid Lipid-Polymer NanoparticlesSemantic proximity Read ↗

Effective viral-mediated lung gene therapy: is airway surface preparation necessary?Semantic proximity Read ↗

Nebulisation of Receptor-Targeted Nanocomplexes for Gene Delivery to the Airway EpitheliumSemantic proximity Read ↗

Discovery of peptides for targeted delivery of mRNA lipid nanoparticles to cystic fibrosis lung epitheliaSemantic proximity Read ↗

Quantitative imaging of plasmid DNA in human airway epithelial cells following non-viral gene transferSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.