Article
Post-transcriptional regulation of the human inducible nitric oxide synthase (iNOS) expression by the cytosolic poly(A)-binding protein (PABP).
Nitric oxide : biology and chemistry - 1 Sept 2013
Casper Ingrid, Nowag Sebastian, Koch Kathrin, Hubrich Thomas, Bollmann Franziska, Henke Jenny, Schmitz Katja, Kleinert Hartmut, Pautz Andrea
Abstract excerpt
Affinity purification using the 3'-untranslated region (3'-UTR) of the human inducible nitric oxide synthase (iNOS) mRNA identified the cytosolic poly(A)-binding protein (PABP) as a protein interacting with the human iNOS 3'-UTR. Downregulation of PABP expression by RNA interference resulted in a marked reduction of cytokine-induced iNOS mRNA expression without changes in the expression of mRNAs coding for the...
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