Article
Myosin I mutants with only 1% of wild-type actin-activated MgATPase activity retain essential in vivo function(s).
Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2001
Liu X, Osherov N, Yamashita R, Brzeska H, Korn E D, May G S
Abstract excerpt
The single class I myosin (MYOA) of Aspergillus nidulans is essential for hyphal growth. It is generally assumed that the functions of all myosins depend on their actin-activated MgATPase activity. Here we show that MYOA mutants with no more than 1% of the actin-activated MgATPase activity of wild-type MYOA in vitro and no detectable in vitro motility activity can support fungal cell growth, albeit with a delay...
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