Article
A gene related to yeast HOS2 histone deacetylase affects extracellular depolymerase expression and virulence in a plant pathogenic fungus.
The Plant cell - 1 Jul 2001
Baidyaroy D, Brosch G, Ahn J H, Graessle S, Wegener S, Tonukari N J, Caballero O, Loidl P, Walton J D
Abstract excerpt
A gene, HDC1, related to the Saccharomyces cerevisiae histone deacetylase (HDAC) gene HOS2, was isolated from the filamentous fungus Cochliobolus carbonum, a pathogen of maize that makes the HDAC inhibitor HC-toxin. Engineered mutants of HDC1 had smaller and less septate conidia and exhibited an approximately 50% reduction in total HDAC activity. Mutants were strongly reduced in virulence as a result of reduced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.