Antiretroviral Therapy Effects on Genetic and Morphologic End Points in Lymphocytes and Sperm of Men with Human Immunodeficiency Virus Infection

Abstract excerpt

Many human immunodeficiency virus (HIV)-infected persons receive prolonged treatment with DNA-reactive antiretroviral drugs. A prospective study was conducted of 26 HIV-infected men who provided samples before treatment and at multiple times after beginning treatment, to investigate effects of antiretrovirals on lymphocyte and sperm chromosomes and semen quality. Several antiretroviral regimens, all including a...

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