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Article

Screening for mutations in the RYR1 gene in families with malignant hyperthermia.

Journal of molecular neuroscience : MN - 1 Jan 2003

Muniz Viviane P, Silva Helga C A, Tsanaclis Ana Maria C, Vainzof Mariz

Abstract excerpt

Malignant hyperthermia (MH) is a potentially lethal pharmacogenetic predisposition associated with a susceptibility to volatile anesthetics and depolarizing muscle relaxants that lead to a fulminant anesthetic crisis with hyperthermia, skeletal muscle rigidity, respiratory and metabolic acidosis, and muscle rhabdomyolysis. Malignant hyperthermia crises are caused by an abnormal regulation of the calcium release...

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Source

Identifiers

PMID: 14500992
DOI: 10.1385/JMN:21:1:35

Genes

RYR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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