Article
In vivo ribozyme targeting of betaAPP+ mRNAs.
Molecular cell biology research communications : MCBRC - 1 Oct 2000
Dolzhanskaya N, Conti J, Merz G, Denman R B
Abstract excerpt
In Alzheimer's disease (AD) and Down's syndrome (DS) patients, posttranscriptional alterations of sequences encoded by exon 9 and exon 10 of the beta-amyloid precursor protein (betaAPP) mRNA result in mutant proteins (betaAPP+) that colocalize with neurofibrillary tangles and senile plaques. These aberrant messages may contribute to the development of sporadic or late-onset Alzheimer's disease; thus, eliminating...
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