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Article

Stimulation of RNA Polymerase II Elongation by Hepatitis Delta Antigen

6 Jul 2001

Abstract excerpt

Transcription elongation by RNA polymerase II (RNAPII) is negatively regulated by the human factors DRB-sensitivity inducing factor (DSIF) and negative elongation factor (NELF). A 66-kilodalton subunit of NELF (NELF-A) shows limited sequence similarity to hepatitis delta antigen (HDAg), the viral protein required for replication of hepatitis delta virus (HDV). The host RNAPII has been implicated in HDV...

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Identifiers

PMID: 11387440
DOI: 10.1126/science.1057925

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