Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human labour is associated with nuclear factor-kappaB activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal'

1 Jun 2001

Abstract excerpt

Human labour is associated with the up-regulation of prostaglandins within the uterus, synthesized via the type-2 cyclo-oxygenase enzyme (COX-2). These lead to remodelling of the fetal membranes and cervix and to stimulation of myometrial contractions. In the human, the principal source of prostaglandins is the amnion. Progesterone acts to promote myometrial quiescence, and in many species the onset of labour is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen and related hormone effects
Share to Inflammatory mediators and NSAID effects
Share to Macrophage Migration Inhibitory Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11385114
DOI: 10.1093/molehr/7.6.581

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human labour is associated with nuclear factor-kappaB activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal'PMID 11385114Read ↗

Nuclear Factor Kappa B Activation Occurs in the Amnion Prior to Labour Onset and Modulates the Expression of Numerous Labour Associated GenesSemantic proximity Read ↗

The role of nuclear factor kappa B in human labourSemantic proximity Read ↗

NF-kappaB and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH)Semantic proximity Read ↗

NF-κB regulates a cassette of immune/inflammatory genes in human pregnant myometrium at termSemantic proximity Read ↗

Interactions between progesterone receptor isoforms in myometrial cells in human labourSemantic proximity Read ↗

Nuclear Factor-Kappa B Regulates Inducible Prostaglandin E Synthase Expression in Human Amnion Mesenchymal Cells1Semantic proximity Read ↗

The relationship between pro-inflammatory cytokines and prostaglandin production in the human amnionSemantic proximity Read ↗

C/EBPδ drives key endocrine signals in the human amnion at parturitionSemantic proximity Read ↗

Expression and Deoxyribonucleic Acid-Binding Activity of the Nuclear Factor κB Family in the Human Myometrium during Pregnancy and LaborSemantic proximity Read ↗

Nuclear factor-kappa B is essential for up-regulation of interleukin-8 expression in human amnion and cervical epithelial cellsSemantic proximity Read ↗

The Role and Regulation of the Nuclear Factor Kappa B Signalling Pathway in Human LabourSemantic proximity Read ↗

The novel inflammatory cytokine high mobility group box protein 1 (HMGB1) is expressed by human term placentaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.