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Article

Alterations of cell cycle regulators affecting the RB pathway in nonfamilial retinoblastoma.

Human pathology - 1 May 2001

Orjuela M, Orlow I, Dudas M, Ponce-Castañeda M V, Ridaura C, Leal C, Salazar A, Abramson D, Gerald W, Cordon-Cardo C

Abstract excerpt

We undertook the present study to examine alterations affecting the RB pathway in the G1 checkpoint and to determine their potential clinical significance in children affected with nonfamilial retinoblastoma. Using immunohistochemistry, patterns of expression of pRB, p16/INK4A, and E2F1 were analyzed in tissue from a cohort of 86 well-characterized patients with nonfamilial retinoblastoma diagnosed at the...

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Identifiers

PMID: 11381373
DOI: 10.1053/hupa.2001.24325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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