Article
A novel automated strategy for screening cryptic telomeric rearrangements in children with idiopathic mental retardation.
European journal of human genetics : EJHG - 1 May 2001
Colleaux L, Rio M, Heuertz S, Moindrault S, Turleau C, Ozilou C, Gosset P, Raoult O, Lyonnet S, Cormier-Daire V, Amiel J, Le Merrer M, Picq M, de Blois M C, Prieur M, Romana S, Cornelis F, Vekemans M, Munnich A
Abstract excerpt
Cryptic unbalanced subtelomeric rearrangements are known to cause a significant proportion of idiopathic mental retardation in childhood. Because of the limited sensitivity of routine analyses, the cytogenetic detection of such rearrangements requires molecular techniques, namely FISH and comparative genomic hybridisation (CGH). An alternative approach consists in using genetic markers to detect segmental...
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