Cryptic telomeric rearrangements in subjects with mental retardation associated with dysmorphism and congenital malformations

Abstract excerpt

Editor—Cryptic telomeric rearrangements are a significant cause of idiopathic mental retardation. Knight et al 1 found 7.4% of these rearrangements in children with moderate to severe mental retardation. Clinical selection criteria for testing patients with subtelomeric chromosome specific probes are still not clear cut and the importance of other surveys to define this point has been stressed.2With this aim, we...

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