Article
hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay.
Human molecular genetics - 15 May 2001
Pitts S A, Kullar H S, Stankovic T, Stewart G S, Last J I, Bedenham T, Armstrong S J, Piane M, Chessa L, Taylor A M, Byrd P J
Abstract excerpt
We showed recently that mutation of the hMRE11 gene identified a new ataxia telangiectasia-like disorder (ATLD). In this report we describe the genomic organization of the hMRE11 gene and the analysis of a promoter region that appears to direct the divergent transcription of hMRE11 and the adjacent gene. The characterization of the genomic organization of the hMRE11 gene allowed us to determine the basis of an...
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