Article
Association of asthma with beta(2)-adrenergic receptor gene polymorphism and cigarette smoking.
American journal of respiratory and critical care medicine - 1 May 2001
Wang Z, Chen C, Niu T, Wu D, Yang J, Wang B, Fang Z, Yandava C N, Drazen J M, Weiss S T, Xu X
Abstract excerpt
Recent studies have suggested that two polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) gene at codons 16 (arginine to glycine) and 27 (glutamine to glutamate) affect an individual's airway responsiveness, or response to acute or chronic beta(2)-agonist therapy but are not risk factors for asthma. We hypothesize that there is an interaction effect on asthma between the beta(2)AR gene polymorphisms and...
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