Nelfinavir is number 4 -- but should it bat cleanup, or lead off?

Abstract excerpt

Critical issues are addressed concerning when to use nelfinavir, a newly approved protease inhibitor. Because of a resistance mutation that occurs as a result of taking nelfinavir, the following questions arise: if resistance emerges in a patient naive to protease inhibitor therapy, will that person be able to take another protease inhibitor without cross resistance occurring, and if resistant virus emerges after...

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