Article
Autism: evidence of association with adenosine deaminase genetic polymorphism.
Neurogenetics - 1 Mar 2001
Bottini N, De Luca D, Saccucci P, Fiumara A, Elia M, Porfirio M C, Lucarelli P, Curatolo P
Abstract excerpt
Reduced adenosine deaminase (ADA) activity has been reported in sera of autistic children relative to controls. Additionally, the Asn allele of the ADA Asp8Asn polymorphism has been associated with reduced enzymatic activity. Therefore, we studied this polymorphism in autistic children and controls from two Italian populations. We observed a significantly elevated frequency of the low-activity Asn allele in the...
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