Article
The missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption.
Human genetics - 1 Mar 2001
Yoshimura T, Yoshimura M, Tabata A, Yasue H, Okamura H
Abstract excerpt
We recently identified a missense variant (Glu298Asp) that lies within exon 7 of the endothelial nitric oxide synthase (eNOS) gene, and that is associated with severe preeclampsia (proteinuric hypertension that develops as a consequence of pregnancy). Maternal hypertension is the most consistently identified factor predisposing to placental abruption. Our objective, therefore, was to analyze the association...
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