Ototoxicity Associated with Use of Nucleoside Analog Reverse Transcriptase Inhibitors: A Report of 3 Possible Cases and Review of the Literature

Abstract excerpt

Although a variety of adverse effects have been attributed to treatment with nucleoside analog reverse transcriptase inhibitors (NRTIs) for human immunodeficiency virus type 1 (HIV-1) infection, only 5 cases of ototoxicity have been reported in the literature. We describe 3 additional cases of possible NRTI-associated ototoxicity in HIV-1-infected patients, all of whom were aged >45 years, had a history of...

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