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Article

Activation of TRAF5 and TRAF6 signal cascades negatively regulates the latent replication origin of Epstein-Barr virus through p38 mitogen-activated protein kinase.

Journal of virology - 1 Jun 2001

Shirakata M, Imadome K I, Okazaki K, Hirai K

Abstract excerpt

Latent Epstein-Barr virus (EBV) is maintained by the virus replication origin oriP that initiates DNA replication with the viral oriP-binding factor EBNA1. However, it is not known whether oriP's replicator activity is regulated by virus proteins or extracellular signals. By using a transient replication assay, we found that a low level of expression of viral signal transduction activator latent membrane protein...

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Source

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Identifiers

PMID: 11333886
DOI: 10.1128/JVI.75.11.5059-5068.2001
PMCID: PMC114910

Genes

TRAF6
TRAF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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