Article
Genome mining for human cancer genes: wherefore art thou?
Trends in molecular medicine - 1 May 2001
Boyer T G, Chen P L, Lee W H
Abstract excerpt
In an initial data-mining effort, the draft human genome was searched to find paralogs of known tumor suppressor genes, and for gene arrangements, which are typical of oncogenes, in cancer cells. The results were disappointing, indicating that although knowledge of the human genome will undoubtedly be of great help, other approaches to identify new oncogenes are needed.
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