Mechanical Strain Effect on Bone-Resorbing Activity and Messenger RNA Expressions of Marker Enzymes in Isolated Osteoclast Culture

Abstract excerpt

Adaptive modeling and remodeling are controlled by the activities of osteoblasts and osteoclasts, which are capable of sensing their mechanical environments and regulating deposition or resorption of bone matrix. The effects of mechanical stimuli on isolated osteoclasts have been scarcely examined because it has proven to be difficult to prepare a number of pure osteoclasts and to cultivate them on mineralized...

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