A putative, ubiquitin-dependent mechanism for the recognition and elimination of defective spermatozoa in the mammalian epididymis

Abstract excerpt

The normal structure and function of sperm are prerequisites for successful fertilization and embryonic development, but little is known about how defective sperm are eliminated during mammalian spermatogenesis. Here, we describe a ubiquitin-dependent, sperm quality control mechanism that resides in the mammalian epididymis, the site of sperm maturation and storage. We used immunofluorescence, electron...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Reproductive Biology and Fertility
• Share to Sperm and Testicular Function
• Share to Ubiquitin and proteasome pathways