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Host defense functions of the epididymal amyloid matrix

11 Nov 2022

Abstract excerpt

The epididymal lumen is an immunologically distinct environment. It maintains tolerance for the naturally antigenic spermatozoa to allow their maturation into functional cells while simultaneously defending against pathogens that can ascend the male tract and cause infertility. We previously demonstrated that a nonpathological amyloid matrix that includes several cystatin-related epididymal spermatogenic (CRES)...

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PMID: 36367296
DOI: 10.1093/molehr/gaac038

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