<i>Trypanosoma brucei brucei</i> crosses the blood–brain barrier while tight junction proteins are preserved in a rat chronic disease model

Abstract excerpt

African trypanosomiasis, sleeping sickness in humans, is caused by the systemic infection of the host by the extracellular parasite, the African trypanosome. The pathogenetic mechanisms of the severe symptoms of central nervous system involvement are still not well understood. The present study examined the routes of haematogenous spread of Trypanosoma brucei brucei (Tbb) to the brain, in particular on the...

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