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Extracellular matrix composition determines the transcriptional response to epidermal growth factor receptor activation

3 Apr 2001

Abstract excerpt

The transcriptional response to epidermal growth factor (EGF) was examined in a cultured cell model of adhesion. Gene expression was monitored in human embryonic kidney cells (HEK293) after attachment of cells to the extracellular matrix (ECM) proteins, laminin, and fibronectin, by using complementary DNA microarrays printed with 1,718 individual human genes. Cluster analysis revealed that the influence of EGF on...

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PMID: 11287658
DOI: 10.1073/pnas.081069098

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