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Article

Distinct domains mediate the early and late functions of the Drosophila ovarian tumor proteins.

Mechanisms of development - 1 Apr 2001

Glenn L E, Searles L L

Abstract excerpt

The Drosophila melanogaster ovarian tumor (otu) gene encodes two novel protein isoforms that are required at multiple stages of oogenesis. We have examined the activity of a set of C-terminal truncation Otu proteins as well as a GFP-tagged Otu (Otu-GFP). These experiments have shown that a putative Tudor domain in the central region of the large Otu isoform and a separate domain in the C-terminal region are...

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PMID: 11287191
DOI: 10.1016/s0925-4773(01)00314-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Distinct domains mediate the early and late functions of the Drosophila ovarian tumor proteins.PMID 11287191Read ↗

A specific ovarian tumor protein isoform is required for efficient differentiation of germ cells in Drosophila oogenesis.Semantic proximity Read ↗

The ovarian tumor protein isoforms of Drosophila melanogaster exhibit differences in function, expression, and localization.Semantic proximity Read ↗

tudor, a posterior-group gene of Drosophila melanogaster, encodes a novel protein and an mRNA localized during mid-oogenesis.Semantic proximity Read ↗

The Drosophila gene fs(2)cup interacts with otu to define a cytoplasmic pathway required for the structure and function of germ-line chromosomes.Semantic proximity Read ↗

<i>Tudor domain containing protein 5-like</i> ( <i>Tdrd5l</i> ) identifies a novel germline body and regulates maternal RNAs during oogenesisSemantic proximity Read ↗

Genetic and molecular characterization of P element-induced mutations reveals that the Drosophila ovarian tumor gene has maternal activity and a variable null phenotype.Semantic proximity Read ↗

Identification of a genomic DNA fragment containing the Drosophila melanogaster ovarian tumor gene (otu) and localization of regions governing its expression.Semantic proximity Read ↗

C-terminal moiety of Tudor contains its in vivo activity in Drosophila.Semantic proximity Read ↗

Novel role of specific Tudor domains in Tudor-Aubergine protein complex assembly and distribution during Drosophila oogenesis.Semantic proximity Read ↗

Valois, a component of the nuage and pole plasm, is involved in assembly of these structures, and binds to Tudor and the methyltransferase Capsuléen.Semantic proximity Read ↗

Structure and expression of hybrid dysgenesis-induced alleles of the ovarian tumor (otu) gene in Drosophila melanogaster.Semantic proximity Read ↗

Regulatory and functional interactions between ovarian tumor and ovo during Drosophila oogenesis.Semantic proximity Read ↗

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