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Article

Mutational analysis of beta-thalassemia cases from the Aegean region of Turkey using an allele-specific oligonucleotide hybridization technique.

Acta haematologica - 1 Jan 2000

Güleşken S, Oren H, Vergin C, Sanli N, Gülen H, Uçar C, Irken G

Abstract excerpt

The aim of the present study was to evaluate the point mutations of beta-thalassemia patients from the Aegean region of Turkey by using an allele-specific oligonucleotide hybridization technique. DNA isolated from peripheral blood samples of 75 children with beta-thalassemia major or intermedia was analyzed using a Bio-Rad mD(x)(TM)-Be Tha Gene 1 kit. We determined mutations in 56 (74.6%) patients. The allelic...

Topics

Alleles
Child
DNA Mutational Analysis
Gene Frequency
Genetic Testing
Genotype
Humans
Nucleic Acid Hybridization
Oligonucleotide Array Sequence Analysis
Point Mutation
Time Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Turkey

beta-Thalassemia

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Identifiers

PMID: 11279308
DOI: 10.1159/000046512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11279308-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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