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Article

Coreceptor choice and T cell depletion by R5, X4, and R5X4 HIV-1 variants in CCR5-deficient (CCR5delta32) and normal human lymphoid tissue.

Virology - 15 Mar 2001

Malkevitch N, McDermott D H, Yi Y, Grivel J C, Schols D, De Clercq E, Murphy P M, Glushakova S, Collman R G, Margolis L

Abstract excerpt

Coreceptor utilization by HIV-1 is an important determinant of pathogenesis. However, coreceptor selectivity is defined in vitro, while in vivo critical pathogenic events occur in lymphoid tissues. Using pharmacological inhibitors, we recently provided evidence that coreceptor selectivity by the...

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Topics

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Share to CD4 Lymphocyte Count
Share to Cytopathogenic Effect, Viral
Share to HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Lymphoid Tissue

Share to Receptors, CCR5

Share to Receptors, CXCR4

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Source

Identifiers

PMID: 11277696
DOI: 10.1006/viro.2000.0807

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11277696-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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