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Article

Positive and Negative Selection in the DAZ Gene Family

1 Apr 2001

Abstract excerpt

Because a microdeletion containing the DAZ gene is the most frequently observed deletion in infertile men, the DAZ gene was considered a strong candidate for the azoospermia factor. A recent evolutionary analysis, however, suggested that DAZ was free from functional constraints and consequently played little or no role in human spermatogenesis. The major evidence for this surprising conclusion is that the...

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Identifiers

PMID: 11264403
DOI: 10.1093/oxfordjournals.molbev.a003831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Positive and Negative Selection in the DAZ Gene FamilyPMID 11264403Read ↗

Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations.Semantic proximity Read ↗

The human DAZ genes, a putative male infertility factor on the Y chromosome, are highly polymorphic in the DAZ repeat regions.Semantic proximity Read ↗

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The human autosomal gene DAZLA: testis specificity and a candidate for male infertilitySemantic proximity Read ↗

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Human BOULE gene rescues meiotic defects in infertile fliesSemantic proximity Read ↗

The roles of the DAZ family in spermatogenesisSemantic proximity Read ↗

High frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermiaSemantic proximity Read ↗

Expression patterns and transcript concentrations of the autosomal DAZL gene in testes of azoospermic menSemantic proximity Read ↗

DAZ gene copies: evidence of Y chromosome evolution.Semantic proximity Read ↗

Putative biological functions of the DAZ family.Semantic proximity Read ↗

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