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Article

The human autosomal gene DAZLA: testis specificity and a candidate for male infertility

1 Dec 1996

Abstract excerpt

The DAZ (Deleted in AZoospermia) and DAZLA (DAZ-like autosomal) genes may be determinants of male infertility. The DAZ gene on the long arm of the human Y chromosome is a strong candidate for the 'azoospermia factor' (AZF). Its role in spermatogenesis is supported by its exclusive expression in testis, its deletion in a high percentage of males with azoospermia or severe oligospermia, and its homology with a...

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Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Sexual Differentiation and Disorders
Sperm and Testicular Function

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8968756
DOI: 10.1093/hmg/5.12.2013

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Click a neighbor to travelStep 1 · 12 closest

The human autosomal gene DAZLA: testis specificity and a candidate for male infertilityPMID 8968756Read ↗

A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonadsSemantic proximity Read ↗

The DAZL1 gene is expressed in human male and female embryonic gonads before meiosisSemantic proximity Read ↗

Expression patterns and transcript concentrations of the autosomal DAZL gene in testes of azoospermic menSemantic proximity Read ↗

A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype.Semantic proximity Read ↗

The human DAZ genes, a putative male infertility factor on the Y chromosome, are highly polymorphic in the DAZ repeat regions.Semantic proximity Read ↗

Infertility-associated DAZL mutations and their effects on DAZL functionsSemantic proximity Read ↗

Partial rescue of the Dazl knockout mouse by the human DAZL gene.Semantic proximity Read ↗

DAZ Family Proteins Exist Throughout Male Germ Cell Development and Transit from Nucleus to Cytoplasm at Meiosis in Humans and Mice1Semantic proximity Read ↗

Human DAZL1 encodes a candidate fertility factor in women that localizes to the prenatal and postnatal germ cells.Semantic proximity Read ↗

A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoansSemantic proximity Read ↗

[DAZL and male infertility: an update].Semantic proximity Read ↗

The roles of the DAZ family in spermatogenesisSemantic proximity Read ↗

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