Article
BRCA1 and BRCA2 mutations among Finnish ovarian carcinoma families.
International journal of oncology - 1 Apr 2001
Sarantaus L, Auranen A, Nevanlinna H
Abstract excerpt
Germ-line mutations in BRCA1 and BRCA2 predispose to hereditary breast-ovarian cancer syndrome. In Finland, 21 different BRCA1/2 mutations have been identified and 14 of the mutations are founders that account for the great majority of all BRCA1/2 mutations. Our aim was to determine the prevalence of the 21 BRCA1/2 mutations in Finnish ovarian carcinoma families. Mutations were screened in 23 families with at...
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