Article
The pathology of familial breast cancer: Clinical and genetic counselling implications of breast cancer pathology.
Breast cancer research : BCR - 1 Jan 1999
Lalloo F, Evans D G
Abstract excerpt
Approximately 5% of all breast cancers are due to one of the high-risk breast cancer genes BRCA1 and BRCA2, or possibly to a third or fourth moderate- to high-risk gene(s). A further proportion of cases arise in the presence of a less striking family history, with later average age at onset and lower penetrance: familial breast cancer. Bilaterality is a recognized feature of hereditary breast cancer. Cancers...
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